Varun Bisessar

Michael Grove

ENGL21003

12/03/2018

1. Introduction: -Research proposal/grant proposal model paper. In this paper, you’d make a case for the value of a particular sort of program for research or line of inquiry in your field, or advocate for an approach to research relevant to your field.

Central Argument: Research regarding the treatment strategies of comorbid OCD in BD lacks evidence and is limited to case reports. Currently a combination of SSRIs and mood stabilization techniques are the only effective treatments. Use of other conventional pharmacological agents and psychotherapy for treating comorbid OCD in BD must be researched in the United States to eliminate the clinical complications produced by studies conducted in eastern countries.

1. Body: -background information

• Statement of the current problem created by the research produced by eastern countries
• Possible studies that can be conducted as produced in the model sources
• Necessary resources/ groups of patients to be studies/ how to evaluate the findings
• Conclusion: – Personal perspective of the studies to craft a study of my own
• Do not present an outcome of any sort
• Model sources along with my crafting of a study only propose an approach to research relevant to the clinical complication currently surrounding the issue.

 

 

Potential Start:

Clinical complications regarding bipolar-OCD and the largely understudied treatments

Patients who suffer from bipolar-OCD often experience the dilemmas resulting from the lack of treatment studies. Disparities between the discussion of bipolar-OCD in eastern countries and the United States becomes evident when patients are faced with the inconvenience of SSRIs and psychotherapy. In the United States alone there are three million bipolar cases and two hundred thousand obsessive compulsive cases documented annually. Recent evidence indicates that SSRIs and mood stabilization techniques are relatively effective treatments, however the use of medication has not been approved because of lackluster evidence and limited case reports. The use of other conventional pharmacological agents and psychotherapy for treating comorbid OCD in BD must be researched in the United States to eliminate the clinical complications produced by studies conducted in eastern countries.

In 1995, a study conducted in Germany revealed that patients with a primary diagnosis of bipolar disorder had experienced other mental disorders, prevalent were symptoms of OCD (Shi, 2015). The limitations of bipolar-OCD research have partly decreased because of the recent publications. Previously vast publications had not specified whether the groups they studied were experiencing manic episodes during the study time frame. Manic episodes increase the occurrence of obsessive-compulsive symptoms which could have resulted in wrongful diagnosis of patients. Also, as attention towards these patients has grown, the research produced must also grow. Many of these studies are conducted in India and China, the scale size of the research groups has limited the number of patients that can be studied. The studies currently available have not declared a funding source which may reason the limitations of research.

The lack of a funding source limits the size of the patient studied, this becomes an issue because of the locations where the current studies were conducted. Cultural homogeneity is one of the factors that contributes to the difficulty in analyzing data produced by studies in eastern regions. The role of cultural homogenous locations such as China removes the factor of genetic diversity which may account for biased results in a publication. Conducting a study to test the best methods of treatment for bipolar-OCD in the United States would be much more challenging because scientists would have to account for all genetic variables. Currently patients experiencing symptoms of bipolar-OCD are being treated with methods adopted from eastern publications. Although the use of SSRIs and psychotherapy can manage the symptoms there is a severe inconvenience for those who SSRIs do not work for. Also, efforts to study the effects of medications used for the separate disorders can help determine if the development of medication for bipolar-OCD is viable.

Possible References:

Amerio, A., Stubbs, B., Odone, A., Tonna, M., Marchesi, C., & Nassir Ghaemi, S. (2016). Bipolar I and II Disorders; A Systematic Review and Meta-Analysis on Differences in Comorbid Obsessive-Compulsive Disorder. Iranian journal of psychiatry and behavioral sciences, 10(3).

American Psychiatric Association. (2013). Diagnostic and statistical manual of mental disorders. American Psychiatric Publishing, 5.

Amerio, A., Tonna, M., Odone, A., Stubbs, B., & Ghaemi, S. N. (2015). Heredity in comorbid bipolar disorder and obsessive-compulsive disorder patients. Shanghai archives of psychiatry, 27(5), 307-310.

Chandran, N., Parmar, A., & Deb, K. S. (2017). A Rare Presentation of a Case of Obsessive-compulsive Disorder Comorbid with Bipolar Affective Disorder. Indian journal of psychological medicine, 39(6), 794-796.

Kazhungil, F., Cholakottil, A., Kattukulathil, S., Kottelassal, A., & Vazhakalayil, R. (2017). Clinical and familial profile of bipolar disorder with and without obsessive-compulsive disorder: an Indian study. Trends in Psychiatry and Psychotherapy, 39(4), 270-275.

Kazhungil F, Mohandas E. (2016). Management of obsessive-compulsive disorder comorbid with bipolar disorder. Indian J Psychiatry, 58(3), 259-269.

Martin Cederlöf, Paul Lichtenstein, Henrik Larsson, Marcus Boman, Christian Rück, Mikael Landén, David Mataix-Cols. (2015). Obsessive-Compulsive Disorder, Psychosis, and Bipolarity: A Longitudinal Cohort and Multigenerational Family Study, Schizophrenia Bulletin, 41(5), 1076–1083.

Rajnarayan, M., Reddy, Y. C., Bada, S. (2011). Obsessive-compulsive disorder with and without bipolar disorder. Psychiatry & Clinical Neurosciences, 65(5), 423-233.

Shi S. (2015). Obsessive compulsive symptoms in bipolar disorder patients: a comorbid disorder or a subtype of bipolar disorder. Shanghai archives of psychiatry, 27(4), 249-51.